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Calcitonin has an importantrole in regulating serum calcium levels in lower animals;however, its physiological role in humans remains elusive.Calcitonin lowers blood calcium levels by suppressing theresorptive action of osteoclasts and promotes calcium de-position in bones by increasing the rate ofosteoid calcifica-tion. Decreasing frequencyalso improves CO2 elimination by increasingdelivered tidal volumes. 283), Graves’disease, or an endemic goiter, the thyroidgland may be palpated.An enlarged, tendergland may result from thyroiditis. Clinical criteria moststrongly suggestive of GCA include jaw claudication,CRP above 2.45 mg/dl, neck pain, an ESR of 47 mm/hor more, and age greater than 75 years, in approximatelythat order (Hayreh et al., 1997)

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